Conformation therapy using a computer controlled telecobalt unit for advanced cervical carcinoma.

This retrospective analysis evaluates the results of conformation radiotherapy for patients with advanced cervical carcinoma. Between January 1980 and September 1987, 16 patients with high common iliac/para-aortic node metastases from advanced carcinoma of the uterine cervix were treated using conformation radiotherapy. A large area from L1/L2 to the pelvis, with an average length of 23 cm, was treated to a total tumour dose of 5000-5500 cGy, with a daily tumour dose of 180-200 cGy in 28-30 daily fractions, using a computer controlled tracking cobalt unit (CCTCU).

Incidence of cataracts after single fraction total body irradiation: the role of steroids and graft versus host disease.

Eighty-eight patients who received single fraction total body irradiation (sfTBI) as part of their conditioning for allogeneic BMT have been evaluated for the risk of cataract formation. Thirty-eight (43%) have developed cataracts; 11 required surgery. With 9.

Graft rejection following HLA matched T-lymphocyte depleted bone marrow transplantation.

Bone marrow graft rejection following HLA-matched bone marrow transplantation (BMT) for leukaemia has been a rare problem. However, with the introduction of T-lymphocyte depleted BMT, graft rejection is recognized as a new complication. At the Royal Free Hospital (RFH) in London T-depletion is achieved using two monoclonal antibodies with complement mediated lysis.

Conformation therapy: a method of improving the tumour treatment volume ratio.

Restriction of the volume irradiated is a fundamental tenet of radiotherapy. Conventional two-dimensional treatment results in geometrically shaped high-dose regions, the sizes of which are defined by the greatest dimensions of a tumour mass. Conformation therapy permits a tumour to be considered for treatment as multiple short segments, and the radiation field to be tailored to fit each segment accurately.

Treatment of medulloblastoma using a computer-controlled tracking cobalt unit.

Radiation therapy of the length of the spinal column presents various clinical and physical problems. The completed plan may be complicated to set up, be time-consuming and require daily variation to achieve reasonable dose homogeneity. A case of medulloblastoma is used to illustrate the steps in producing a plan for dynamic treatment using a computer-controlled tracking cobalt unit.