Publications by authors named "D Sivaraj"
C-X-C motif chemokine ligand 12 (CXCL12; Stromal Cell-Derived Factor 1 [SDF-1]), most notably known for its role in embryogenesis and hematopoiesis, has been implicated in tumor pathophysiology and neovascularization. However, its cell-specific role and mechanism of action have not been well characterized. Previous work by our group has demonstrated that hypoxia-inducible factor (HIF)-1 modulates downstream CXCL12 expression following ischemic tissue injury.
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- The FOXC2 transcription factor is linked to aggressive basal-like breast cancers and issues like lymphedema, which can lead to chronic wounds and increase cancer risk.
- A study using mouse models revealed that Foxc2 mice had delayed wound healing and larger scar areas compared to wildtype mice.
- The findings suggest that FOXC2 plays a crucial role in skin wound healing and may contribute to fibrosis and immune cell differences, highlighting its potential impact on cancer development in older adults.
In this study, we present the first-in-human use of topical deferoxamine (DFO) in the treatment of a beta-thalassemia wound. We elected to use DFO on a patient that suffered from a chronic nonhealing wound in the setting of beta-thalassemia. Despite approximately 55 weeks of marginal improvement in healing, this patient's wound healed completely after 21 weeks of treatment with DFO.
View Article and Find Full Text PDFElevated shear stress (ESS) induces vascular remodeling in veins exposed to arterial blood flow, which can lead to arteriovenous (AV) fistula failure. The molecular mechanisms driving remodeling have not been comprehensively examined with a single-cell resolution before. Using an animal mode, single-cell RNA sequencing, and histopathology, we precisely manipulate blood flow to comprehensively characterize all cell subpopulations important during vascular remodeling.
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- The study investigates the healing effects of two compounds, avenanthramide (AVN) and β-Glucan, on acute and chronic wounds using a mouse model that mimics human wound healing.
- The results show that both compounds at a 1% dose enhance healing by improving tissue architecture and accelerating recovery time, with AVN reducing inflammation and β-Glucan promoting blood vessel formation.
- Understanding the specific mechanisms of these compounds is crucial for their potential application in human wound care, as they exhibit distinct healing properties.