Publications by authors named "D Simkin"
Article Synopsis
- Gliomas consist of malignant cells that exhibit various cellular states, which are organized in distinct ways within the tumor.
- Research reveals three key modes of organization: localized environments with predominant cellular states, specific pairings of these states residing close to one another, and a global architecture consisting of five layers driven by hypoxia.
- The study emphasizes that hypoxia influences the spatial arrangement of these cellular states, while regions far from hypoxic areas show less organization, offering a novel framework for understanding glioma structure.
Article Synopsis
- * Researchers integrated data from 77 studies, evaluating 1,163 tumor samples across 24 types, and identified 41 consensus meta-programs representing distinct gene expression patterns related to ITH.
- * The findings suggest that many of these meta-programs in cancer cells mirror those in non-malignant cells, indicating that some variations in ITH exist even before cancer develops, and the comprehensive dataset is now available for further research on the Curated Cancer Cell Atlas website.
Autism Spectrum Disorder and Complementary-Integrative Medicine.
Child Adolesc Psychiatr Clin N Am
April 2023
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects 0.6%-1.7% of children.
View Article and Find Full Text PDFComplementary and Integrative Approaches to Prevention and Treatment of Child and Adolescent Obesity.
Child Adolesc Psychiatr Clin N Am
April 2023
Childhood obesity is a significant global challenge with increasing prevalence. It is associated with long-term health risks. Interventions especially early on can be effective in the prevention and reducing the impact on health in children.
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