Publications by authors named "D Sidransky"
Article Synopsis
- The study investigates how cancer cells influence the fitness of surrounding tumor microenvironment (TME) cells through a mechanism involving a long non-coding RNA called Tu-Stroma, which alters the expression of Flower isoforms, impacting their growth advantage.
- The expression of Flower Win isoforms in cancer cells enhances their dominance over TME cells that express Flower Lose isoforms, leading to reduced fitness in the TME.
- Targeting Flower proteins with a humanized monoclonal antibody in mice has shown promising results, significantly reducing cancer growth and metastasis while improving survival rates and protecting organs from potential lesions.
Article Synopsis
- * The study involved various experiments to determine how YAP1 affects the tumor immune microenvironment (TIME), revealing that YAP1 influences immune components via the IL-6/STAT3 pathway and chemokines.
- * Results showed that reducing YAP1 levels decreases immunosuppressive cells in the TIME, suggesting that targeting YAP1 alongside traditional immunotherapy could improve treatment outcomes for UCB patients.
Article Synopsis
- Late-stage cancers have limited treatment options, making early diagnosis crucial for improving patient outcomes and reducing mortality.
- Molecular markers, specifically DNA methylation, show potential for facilitating early cancer detection through various testing methods.
- The study assessed different bisulfite conversion kits for analyzing DNA from cervical samples, finding similar performance across kits and highlighting the efficiency of automated processes in increasing testing throughput.
Evaluation of self-collected nasal, urine, and saliva samples for molecular detection of SARS-CoV-2 using an EUA approved RT-PCR assay and a laboratory developed LAMP SARS-CoV-2 test.
Ana Purcell-Wiltz Fernando Tadeu Zamuner Karem Caraballo Lorena De Jesus Yaima Miranda David Sidransky
Immun Inflamm Dis
June 2024
As the SARS-CoV-2 virus spread throughout the world, millions of positive cases of COVID-19 were registered and, even though there are millions of people already vaccinated against SARS-CoV-2, a large part of the global population remains vulnerable to contracting the virus. Massive nasopharyngeal sample collection in Puerto Rico at the beginning of the pandemic was limited by the scarcity of trained personnel and testing sites. To increase SARS-CoV-2 molecular testing availability, we evaluated the diagnostic accuracy of self-collected nasal, saliva, and urine samples using the TaqPath reverse transcription polymerase chain reaction (RT-PCR) COVID-19 kit to detect SARS-CoV-2.
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