Publications by authors named "D Shimba"
Proton pump inhibitors (PPIs) are the most commonly used anti-acid drugs worldwide, including among cancer patients. However, drug-drug interactions between PPIs and other agents may lead to decreased drug absorption with possible reduced therapeutic benefit, or even increased toxicity. Unfortunately, only scarce data exist regarding the safety of concomitant PPI use with anti-cancer agents.
View Article and Find Full Text PDFAntibiotics have been extensively used to treat infectious diseases over the past century and have largely contributed to increased life expectancy over time. However, antibiotic use can impose profound and protracted changes to the diversity of the microbial ecosystem, affecting the composition of up to 30% of the bacterial species in the gut microbiome. By modifying human microbiota composition, antibiotics alter the action of several oncologic drugs, potentially leading to decreased efficacy and increased toxicities.
View Article and Find Full Text PDFArticle Synopsis
- Microsatellite instability (MSI) and POLD1 mutations are more common in colorectal tumours related to polyposis syndrome, but rarely occur in breast tumours.
- A case of a young patient with a metastatic luminal B breast tumour and a strong family history of cancer revealed a Variant of Uncertain Significance (VUS) in POLD1, leading to further investigation of MSI which tested positive.
- Current research suggests that pembrolizumab, an immunotherapy drug, may be a more effective treatment for tumours showing MSI compared to traditional chemotherapy.
Aims And Background: Cervical intraepithelial neoplasia (CIN) grade II-III is being diagnosed in younger women and, because of the reproductive age range for women and the habits associated with a modern lifestyle, is now affecting a broad age range. Surgical treatment for CIN has been associated with premature amenorrhea, low birth weight, and premature labor and birth. It is therefore imperative to develop clinical treatments for CIN, such as conservative treatment with interferons.
View Article and Find Full Text PDFIntroduction: Conservative treatment with intralesional interferon (IFN) is a therapeutic option for cervical intraepithelial neoplasia (CIN) patients of childbearing age.
Materials And Methods: The study group was made up of patients diagnosed with a high-grade lesion and treated with intralesional human recombinant IFNalpha-2b. Vaginal secretion was collected during IFNalpha-2b treatment for analysis of cytokines and viral load.