Publications by authors named "D Shearer"
Introduction: As the drug toxicity crisis continues to evolve globally, harms related to non-opioid substances, including stimulants, have risen in parallel. Our study aims were to describe trends in accidental stimulant toxicity deaths and to characterize demographic characteristics of decedents and the circumstances surrounding death.
Methods: We conducted a population-based repeated cross-sectional study, of all accidental stimulant toxicity deaths between January 1, 2018, and December 31, 2021, in Ontario, Canada.
We used our mouse papillomavirus (MmuPV1) model to test the hypothesis that two primary psychoactive ingredients of marijuana, Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD), promote papillomavirus persistence in the oral mucosa of infected mice. We conducted intraperitoneal (ip) injections of a moderate dose (3 mg/kg) of either CBD and/or THC in both male and female athymic nude mice and followed the mice up to 20 weeks post-infection. These doses are comparable to what is estimated for human conventional cannabis consumption.
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- Cottontail rabbit papillomavirus (CRPV) serves as a key model for studying how certain viruses cause tumors, yet research has been hindered by a lack of comprehensive data on its transcriptome.
- The study developed a complete transcription map of CRPV using various advanced techniques, revealing distinct early and late RNA transcripts produced from five main promoters and two polyadenylation sites.
- It was found that CRPV undergoes significant alternative splicing, generating over 33 RNA isoforms that produce at least 12 viral proteins, thereby providing insights into how CRPV contributes to tumor development.
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- A study found that 42% of women who faced intimate partner violence (IPV) suffered injuries, highlighting the issue of IPV-related injuries in low- and middle-income countries (LMICs).
- A systematic review analyzed literature from various LMICs, identifying common injury types (soft tissue injuries, fractures, burns) and locations (head, neck, face).
- The findings emphasize the need for healthcare providers to be aware of IPV-related injuries in LMICs, although the study's limitation is that it focused only on English-language literature.
Combined action observation and motor imagery (AOMI) training improves motor skill performance, but limited research has investigated possible moderating factors for this intervention. This study examined the influence of action observation (AO) perspective on the effectiveness of AOMI training for novices learning a 'shadow' Osoto Gari judo throw. Thirty novice participants were randomly assigned to AOMI training that displayed egocentric footage (AOMI) or allocentric footage (AOMI) of the Osoto Gari, or Control training.
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