Publications by authors named "D Severijns"
Background: Gait characteristics and their changes during the 6-minute walking test (6MWT) in people with multiple sclerosis (pwMS) have been described in the literature, which one may refer to as walking fatigability in the body function level of the International Classification of Functioning, Disability, and Health. However, whether these metrics are reliable is unknown.
Objective: To investigate the between-day reliability of the gait characteristics and their changes in pwMS and healthy controls (HCs).
Article Synopsis
- * Among 84 RMS patients analyzed, 72.6% maintained 'no evidence of disease activity' (NEDA-3) status after a mean follow-up of 22.6 months, while some experienced relapses or disability progression, especially those with a history of multiple treatments.
- * The safety profile was mostly acceptable, with 67.9% experiencing at least one adverse event, primarily fatigue and skin issues, reaffirming cladribine's
Objective: To summarize the literature on definitions, assessment protocols, and outcome measures for motor fatigability in patients with neurologic problems and investigates the known clinimetric properties according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria.
Data Sources: Two databases were consulted for studies published between January 2003 and November 2018 using the terms "motor fatigability," "nervous system disease," and "upper limb."
Study Selection: Studies were included if they were (1) not older than 15 years; (2) written in English, German, or Dutch; (3) involved upper limbs of patients with neurologic disease; and (4) adequately described protocols using maximum voluntary contractions.
Background: Day-to-day reliability and cut-off values to detect abnormal walking fatigability (WF) remain to be investigated in persons with multiple sclerosis (pwMS).
Methods: In all, 49 pwMS (mean Expanded Disability Status Scale (EDSS) ± standard deviation (SD): 3.3 ± 1.