Publications by authors named "D Serre"
Article Synopsis
- - The study investigates how multiple strains of the parasite Plasmodium vivax affect infection in Saimiri monkeys through single cell RNA sequencing and genotyping.
- - Results show that simultaneous infection with two strains can lead to sustained polyclonal infections, but there's no observable difference in how these strains behave in terms of regulation or sexual differentiation.
- - While all parasite genotypes can be transmitted to mosquitoes, not all are successful in causing blood infections, indicating a significant limitation during their early development stages.
Unlabelled: parasites, the causative organism of malaria, caused over 600,000 deaths in 2022. In Mali, causes the majority of malaria cases and deaths and is transmitted seasonally. Anti-malarial immunity develops slowly over repeated exposures to and some aspects of this immunity (e.
View Article and Find Full Text PDFUncovering the complexity of systems in non-model organisms is critical for understanding arthropod immunology. Prior efforts have mostly focused on Dipteran insects, which only account for a subset of existing arthropod species in nature. Here we use and develop advanced techniques to describe immune cells (hemocytes) from the clinically relevant tick Ixodes scapularis at a single-cell resolution.
View Article and Find Full Text PDFIn Bandiagara, Mali, children experience on average two clinical malaria episodes per year. However, even in the same transmission area, the number of uncomplicated symptomatic infections, and their parasitemia, can vary dramatically among children. We simultaneously characterize host and parasite gene expression profiles from 136 Malian children with symptomatic falciparum malaria and examine differences in the relative proportion of immune cells and parasite stages, as well as in gene expression, associated with infection and or patient characteristics.
View Article and Find Full Text PDFArticle Synopsis
- Infections often involve multiple genetically distinct strains of parasites, but how this affects the parasites' development and transmission is not well understood.
- A study of monkeys revealed that while simultaneous infections with two strains resulted in sustained polyclonal infections, there were no significant differences in parasite regulation or sexual differentiation.
- The research also indicated that although all parasite genotypes can be transmitted to mosquitoes, not all contribute equally to blood infections later, suggesting a critical selection process during early development.