CDF family of zinc transporters ZRC-1, MSC-2, and ZRG-17 are involved in survival at high zinc conditions, vegetative development, and cellulase utilization in .

The cation diffusion facilitator (CDF) family of zinc transporters plays a crucial role in zinc homeostasis in eukaryotes, including fungi. Here, we investigated the cell functions and genetic interactions of CDF zinc transporters -1 and -2 in . The Δ-1 mutant could not grow in a high-zinc environment, indicating that the zinc transporter protein ZRC-1 was essential for growth in high-zinc conditions.

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We report an interesting case of a central nervous system vasculitis, presenting with a relapsing remitting nature and a previously unreported profile of cognitive deficits in this variant of the disease.The patient presented with bilateral headache, left eye upper temporal quarter visual field loss, dyschromatopsia and a transient loss of consciousness. He was previously evaluated for similar set of symptoms over the past eight years.

Initial Experience with Tositumomab and I-131-Labeled Tositumomab for Treatment of Relapsed/Refractory Hodgkin Lymphoma.

Purpose: To determine the maximum tolerated dose (MTD) of [I]tositumomab in patients with refractory/recurrent Hodgkin lymphoma (HL) and to preliminarily determine if [I]tositumomab has activity against HL and if positron emission tomography (PET) with 2-deoxy-2-[F]fluoro-D-glucose ([F]DG) performed 6 weeks post-therapy predicted 12-week response.

Procedures: Separate dose-finding studies were performed for patients with and without prior transplant. A single therapeutic total body radiation dose (TBD) of [I]tositumomab was administered.

Prospective study of hemodynamic performances of standard ATS and AP-ATS valves.

Background And Aim Of The Study: Following aortic valve replacement (AVR), a residual transprosthetic gradient can develop which has detrimental long-term effects, especially with regard to left ventricular mass regression and subsequent mortality. The Advanced Performance-ATS valve (AP-ATS) was developed to overcome this potential patient-prosthesis mismatch. In the present study, the early postoperative transprosthetic gradient was determined after AVR with ATS valves 18 to 25, to confirm the promise of superior hemodynamic performance of the AP series and to define respective indications.

Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from rat heart subjected to ischemia and reperfusion.

Ischemia-reperfusion injury to cardiac myocytes involves membrane damage mediated by oxygen free radicals. Lipid peroxidation is considered a major mechanism of oxygen free radical toxicity in reperfused heart. Mitochondrial respiration is an important source of these reactive oxygen species and hence a potential contributor to reperfusion injury.