Publications by authors named "D Seow"
Natural products encompass a diverse range of compounds with high impact applications in consumer care, agriculture and most notably, therapeutics. However, despite the expansive chemical repertoire indicated in genomic information of microbes, only a small subset can be obtained under laboratory conditions. To increase accessible chemical space and realize Nature's full chemical potential, a multi-pronged genetic- and cultivation-based strategy has been employed to activate and upregulate natural product biosyntheses in native and heterologous strains.
View Article and Find Full Text PDFArticle Synopsis
- Paratenon preserving techniques for acute Achilles tendon repair aim to enhance healing by maintaining blood supply and biological function, with the hypothesis that these methods lead to high return-to-play and low complication rates.
- A systematic review was conducted across multiple databases, evaluating evidence quality and performing meta-analyses on complication rates, applying different statistical models based on data heterogeneity.
- Results showed a 90.3% return to play rate, a low rerupture rate of 0.9%, and overall complication rates at 4.8%, indicating that these minimally invasive techniques are both safe and effective for tendon repair.
Background: High-flow nasal oxygen therapy (HFNO) is used in diverse hospital settings to treat patients with acute respiratory failure (ARF). This systematic review aims to summarise the evidence regarding any benefits HFNO therapy has compared with conventional oxygen therapy (COT) for patients with ARF.
Methods: Three databases (Embase, Medline and CENTRAL) were searched on 22 March 2023 for studies evaluating HFNO compared with COT for the treatment of ARF, with the primary outcome being hospital mortality and secondary outcomes including (but not limited to) escalation to invasive mechanical ventilation (IMV) or non-invasive ventilation (NIV).
In recent years, CRISPR-Cas toolboxes for editing have rapidly accelerated natural product discovery and engineering. However, Cas efficiencies are oftentimes strain-dependent, and the commonly used Cas9 (SpCas9) is notorious for having high levels of off-target toxicity effects. Thus, a variety of Cas proteins is required for greater flexibility of genetic manipulation within a wider range of strains.
View Article and Find Full Text PDFTopic: This systematic review and meta-analysis aims to clarify the association of cataract surgery with cognitive impairment and dementia.
Clinical Relevance: The association between vision impairment and cognitive decline is well-established. However, the cognitive benefits of cataract surgery are less clear.