Publications by authors named "D Sedlacek"
Course and complications of influenza A in seniors over 65 years of age.
Cent Eur J Public Health
September 2024
Article Synopsis
- Influenza A and B viruses lead to significant global health issues, causing millions of serious cases and hundreds of thousands of deaths annually, particularly from bacterial complications in seniors over 65.
- A retrospective study analyzed clinical and lab data from 261 seniors treated for influenza at University Hospital Pilsen to understand disease progression and complications.
- Results showed that many patients experienced severe symptoms, with 18% mortality linked to complications, highlighting the need for timely vaccination and preventive measures for at-risk populations.
Background: Although people with HIV might be at risk of severe outcomes from infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; coronavirus 2019 [COVID-19]), regional and temporal differences in SARS-CoV-2 testing in people with HIV across Europe have not been previously described.
Methods: We described the proportions of testing, positive test results, and hospitalizations due to COVID-19 between 1 January 2020 and 31 December 2021 in the EuroSIDA cohort and the factors associated with being tested for SARS-CoV-2 and with ever testing positive.
Results: Of 9012 participants, 2270 (25.
Article Synopsis
- There is ongoing uncertainty about the relationship between SARS-CoV-2 and HIV, specifically regarding the risks for individuals infected with both viruses.
- A study involving 536 HIV-positive patients in central and eastern Europe revealed that low CD4 cell counts and detectable HIV viral loads are linked to increased severity of COVID-19 symptoms.
- Findings suggest that a lower HIV viral load correlates with less severe COVID-19 outcomes, indicating its potential use as a prognostic tool for clinicians treating co-infected patients.
Objective: Over 480 000 Ukrainian refugees have arrived in the Czech Republic since the Russian invasion of Ukraine in 2022, including over 500 people with HIV. This study describes the demographics, characteristics, and management of Ukrainian refugees with HIV in the Czech Republic.
Design: Retrospective, observational, noninterventional study.
Background: For people with HIV and CD4 counts >500 cells/mm, early initiation of antiretroviral therapy (ART) reduces serious AIDS and serious non-AIDS (SNA) risk compared with deferral of treatment until CD4 counts are <350 cells/mm. Whether excess risk of AIDS and SNA persists once ART is initiated for those who defer treatment is uncertain.
Methods: The Strategic Timing of AntiRetroviral Treatment (START) trial, as previously reported, randomly assigned 4684 ART-naive HIV-positive adults with CD4 counts .