Publications by authors named "D Scott Wieland"
Article Synopsis
- Large language models (LLMs) like GPT-J-6B, Llama-3.1-8B, and Mistral-7B can learn chemical properties effectively through fine-tuning without specialized features.
- Fine-tuning these models often outperforms traditional machine learning methods in simple classification tasks, with potential success in more complex problems depending on dataset size and question type.
- The ease of converting datasets for LLM training and the effectiveness of small datasets in generating predictive models suggest that LLMs could significantly streamline experimental processes in chemical research.
The field of bone regeneration has primarily focused on investigating fracture healing and nonunion in isolated musculoskeletal injuries. Compared to isolated fractures, which frequently heal well, fractures in patients with multiple bodily injuries (polytrauma) may exhibit impaired healing. While some papers have reported the overall cytokine response to polytrauma conditions, significant gaps in our understanding remain in how fractures heal differently in polytrauma patients.
View Article and Find Full Text PDFObjective: This study aimed to determine if a history of tinnitus is associated with the risk of developing dementia.
Method: A nationwide population-based case-control study including all eligible adults in Taiwan.
Results: A total of 15 686 patients were included in the study, with 7843 individuals making up each of the case and control groups.
Orthopedic implants made of biodegradable magnesium (Mg) provide an alternative to nondegradable implants for fracture repair. Widely reported to be pro-osteogenic, Mg implants are also believed to be anti-inflammatory and anti-osteoclastic, but this is difficult to reconcile with the early clinical inflammation observed around these implants. Here, by surveying implant healing in a rat bone model, we determined the cellular responses and structural assembly of bone correlated with the surface changes of Mg implants inherent in degradation.
View Article and Find Full Text PDFArticle Synopsis
- Magnesium (Mg) alloys, particularly those with gadolinium, are emerging as promising materials for temporary bone implants due to their biocompatibility and mechanical properties, presenting a potential replacement for traditional titanium and stainless-steel implants.
- A study involving rat tibias over various time periods (10, 20, and 32 weeks) used advanced imaging techniques to evaluate the implants' degradation behavior and their integration with bone tissues.
- Results indicate that the Mg-xGd implants not only form a stable degradation layer and support bone remodeling similar to titanium but also do not accumulate harmful levels of Mg or Gd in organs, making them suitable for use in bone repair.