Publications by authors named "D Schrump"
Article Synopsis
- Acute esophageal necrosis (AEN) is a rare and serious condition marked by black discoloration in the esophagus, often triggered by major stressors like trauma or surgeries, with a mortality rate up to 32%.
- Patients with AEN typically have risk factors such as diabetes, hypertension, and kidney disease, but it can also occur in healthy individuals after surgery.
- Early diagnosis through upper endoscopy and supportive care is crucial to manage AEN effectively and reduce the risk of severe complications.
We report that ~1.8% of all mesothelioma patients and 4.9% of those younger than 55, carry rare germline variants of the BRCA1 associated RING domain 1 ( gene that were predicted to be damaging by computational analyses.
View Article and Find Full Text PDFBackground: Thymoma presents with several autoimmune manifestations and is associated with secondary autoimmune regulator (AIRE) deficiency. Pneumonitis has recently been described as an autoimmune manifestation associated with thymoma presenting with similar clinical, radiographic, histological, and autoantibody features as seen in patients with inherited AIRE deficiency who suffer from Autoimmune PolyEndocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED) syndrome.
Objectives: To treat two patients with biopsy-proven thymoma-associated pneumonitis with lymphocyte-directed immunomodulation.
Drug therapy is vital in cancer treatment. Accurate analysis of drug sensitivity for specific cancers can guide healthcare professionals in prescribing drugs, leading to improved patient survival and quality of life. However, there is a lack of web-based tools that offer comprehensive visualization and analysis of pancancer drug sensitivity.
View Article and Find Full Text PDFArticle Synopsis
- BAP1 tumor predisposition syndrome (TPDS) is linked to an increased risk for several types of cancer, making early detection crucial for patients and their families.
- A study examined nail abnormalities in 47 individuals with known BAP1 variants, revealing that 87.2% of participants had some form of nail issue, including leukonychia and onychopapilloma.
- The findings highlight the prevalence of nail abnormalities among BAP1 TPDS patients, suggesting that these changes could serve as a clinical indicator for further evaluation and monitoring of cancer risk.