Publications by authors named "D Schrag"
Objectives: Fatigue is a common nonhematologic toxicity of the CDK4/6 inhibitor palbociclib in metastatic breast cancer (MBC) patients with prevalence rates of clinician-rated all-grade and grade 3/4 fatigue of 39.2% and 2.5%, respectively.
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- Electronic patient-reported outcomes (ePROs) can enhance cancer patient care, but integrating them into clinical systems poses significant challenges, requiring technical resources, clinician and patient commitment, and institutional support.* -
- The SIMPRO Research Consortium created and implemented eSyM, an ePRO-based symptom management program across six cancer centers, tracking implementation methods and barriers through established frameworks and tools like REDCap.* -
- Out of 226 documented implementation strategies, 64 unique strategies were identified, with universal strategies that were consistently effective focusing on clinical preparation, training, and patient/clinician engagement being seen as particularly impactful.*
Databases that link molecular data to clinical outcomes can inform precision cancer research into novel prognostic and predictive biomarkers. However, outside of clinical trials, cancer outcomes are typically recorded only in text form within electronic health records (EHRs). Artificial intelligence (AI) models have been trained to extract outcomes from individual EHRs.
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- Researchers are merging unstructured patient data with structured health records to create the MSK-CHORD dataset, consisting of varied cancer types from nearly 25,000 patients at Memorial Sloan Kettering Cancer Center.
- This dataset allows for in-depth analysis of cancer outcomes using advanced techniques like natural language processing, revealing new relationships that smaller datasets may not show.
- Using MSK-CHORD for machine learning models, findings suggest that incorporating features from these unstructured texts can better predict patient survival than relying solely on genomic data or cancer staging.