Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout mice.

Traditional NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, and inhibitors of nitric oxide synthase (NOS) impair the healing of preexisting gastric ulcers. However, the role of COX-1 (with or without impairment of COX-2) and the interaction between COX and NOS isoforms during healing are less clear. Thus we investigated healing and regulation of COX and NOS isoforms during ulcer healing in COX-1 and COX-2 deficiency and inhibition mouse models.

[Aphthous esophagitis as an atypical manifestation of a primary HIV-infection].

History: A 56-year-old patient from Burkina Faso (Western Africa), living in Switzerland for 12 years, was referred to hospital because of acute onset of severe painful swallowing. He returned from a 3-week visit to his home country 4 weeks prior to admission. CLINICAL FINDINGS AND INVESTIGATIONS: Whereas clinical and radiological findings were normal, routine laboratory testing showed increased parameters of infection.