Publications by authors named "D Scherr"
In 1924, the Dutch physiologist Willem Einthoven received the Nobel Prize in Physiology or Medicine for his discovery of the mechanism of the electrocardiogram (ECG). Anno 2024, the ECG is commonly used as a diagnostic tool in cardiology. In the paper 'Le Télécardiogramme', Einthoven described the first recording of the now most common cardiac arrhythmia: atrial fibrillation (AF).
View Article and Find Full Text PDF: There are limited data about left atrial appendage closure (LAAC) in patients with cancer. We therefore sought to compare the outcome after LAAC in patients with vs. without cancer in a multicentre registry.
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- The peQasus study evaluates the safety and effectiveness of a new temperature-controlled high-power short-duration (HPSD) radiofrequency catheter (QDOT Micro) for pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF).
- Conducted across 15 centers in Europe, the study involved 1,023 patients and compared outcomes between a very HPSD technique and a hybrid approach.
- Results indicated complete PVI success, a mean procedure time of about 98 minutes, and a similar safety profile for both techniques, with 12-month arrhythmia-free survival rates around 77%.
Computational models of atrial fibrillation (AF) can help improve success rates of interventions, such as ablation. However, evaluating the efficacy of different treatments requires performing multiple costly simulations by pacing at different points and checking whether AF has been induced or not, hindering the clinical application of these models. In this work, we propose a classification method that can predict AF inducibility in patient-specific cardiac models without running additional simulations.
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- Advanced urothelial cancer displays significant genetic diversity and involves complex interactions between internal and external mutagens, which contributes to its deadly nature.
- The study revealed that APOBEC3-induced mutations occur early during tumor development, while chemotherapy leads to a surge of later mutations, with both processes affecting the structure of extrachromosomal DNA.
- Findings emphasized the role of circular ecDNA in the development of treatment resistance, specifically through CCND1 amplifications, highlighting key mechanisms that can inform future cancer therapies.