Publications by authors named "D Sawcer"
Background: Immunocompromised patients, including those with human immunodeficiency virus (HIV), have been observed to have verrucae that are more extensive and treatment-resistant compared to those in immunocompetent patients. However, there is a critical lack of data in the current literature on the characteristics of verruca vulgaris in individuals with HIV.
Methods: This retrospective chart review included a cohort of HIV-positive individuals and a control group of immunocompetent individuals presenting to an outpatient, county hospital-based dermatology clinic for evaluation of verruca vulgaris between the years of 2016 and 2018.
Article Synopsis
- The COVID-19 pandemic has multiple phases, with current treatment strategies largely focusing on late-stage disease in hospitals, while the viral phase in outpatients remains a key issue.* -
- A review of 111 publications identified only 21 focusing on outpatient care, highlighting an imbalance in research and available treatments for patients not requiring hospitalization.* -
- The authors advocate for public health authorities to approve low-risk treatments for outpatients alongside vaccination efforts, especially in light of emerging SARS-CoV-2 variants and limited monoclonal antibody supply.*
Article Synopsis
- COVID-19, caused by the SARS-CoV-2 virus, is a significant health issue that first emerged in December 2019 in Wuhan, China, leading to various treatments being explored over time.
- The text discusses the importance of understanding the different stages and phases of COVID-19 to effectively time the use of therapeutics and improve patient outcomes.
- The authors propose a framework that outlines key periods and phases of the disease, which can help guide research and treatment decisions for COVID-19 therapies.
Nanosecond pulsed electric fields (nsPEF) induce apoptotic pathways in human cancer cells. The potential therapeutic effective of nsPEF has been reported in cell lines and in xenograft animal tumor model. The present study investigated the ability of nsPEF to cause cancer cell death in vivo using carcinogen-induced animal tumor model, and the pulse duration of nsPEF was only 7 and 14 nano second (ns).
View Article and Find Full Text PDFDifferential sensitivities of malignant and normal skin cells to nanosecond pulsed electric fields.
Technol Cancer Res Treat
June 2011
Pulsed electric fields with nanosecond duration and high amplitude have effects on biological subjects and bring new venue in disease diagnosis and therapy. To address this respect, we investigated the responses of paired tumor and normal human skin cells - a basal cell carcinoma (BCC) cell line, and its sister normal cell line (TE) - to nanosecond, megavolt-per-meter pulses. When BCC (TE 354.
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