Publications by authors named "D Savitha"

Background Currently there is little research, especially in India, which has looked at the physiological effects of humour on pain perception. Objective To compare pain sensitivity across the three arms of intervention (control, neutral and funny videos). And to investigate the relationship between a) cardiovascular responses across and within each arm, b) pain sensitivity and resting blood pressure, pulse rate, c) humour trait with pain sensitivity.

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Background Pain perception, with inter-individual variability, is a challenge for both patients and clinicians. Distribution of pain sensitivity parameters being less explored in Indian population can vary with reports from outside India. Objective To describe distribution of pain sensitivity parameters using cold pressor test in healthy adults and to explore relationship of pain sensitivity with gender, vascular reactivity and parental history of hypertension.

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A novel fluorogenic sensor N-benzo[b]thiophen-2-yl-methylene-4,5-dimethyl-benzene-1,2-diamine (BTMPD) was synthesized and characterized by using spectroscopic methods including UV-visible, FT-IR, H NMR, C NMR, and mass spectrometry. The designed fluorescent probe, owing to its remarkable properties, behaves as an efficient turn-on sensor for the sensing of amino acid Serine (Ser). Also, the strength of the probe enhances upon the addition of Ser via charge transfer, and the renowned properties of the fluorophore were duly found.

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Article Synopsis
  • The compound 4-(5-nitro-thiophen-2-yl)-pyrrolo[1,2-a] quinoxaline (5NOTAAPP) was synthesized through a simple, catalyst-free method, using 5-nitro-2-thiophene carboxaldehyde and 1-(2-aminophenyl)pyrrole and was characterized using several spectroscopic techniques.
  • Structural confirmation was achieved via single-crystal X-ray diffraction, revealing a monoclinic crystal structure with specific unit cell dimensions.
  • Molecular docking studies suggest that 5NOTAAPP effectively inhibits the Main protease 3CL associated with the COVID-19 virus, indicating its potential as a therapeutic agent.
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Background: The influence of repeated exposures to cold pain stimulus, a surrogate of clinical pain, has remained largely unexplored. The study was planned to test the effect of repeated exposures to cold pain through cold pressor task on pain sensitivity and vascular reactivity.

Methods: Single-group experimental study.

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