Publications by authors named "D Sathishkumar"
Vitamin D-dependent rickets type 2A (VDDR2A) is a rare cause of infantile-onset alopecia, characterized by severe hypotrichosis, small cutaneous cysts, early-onset treatment-resistant rickets, and hypocalcemia. Alopecia, often starting a few weeks to months after birth, may be the presenting feature. We present three cases of VDDR2A with genetic variants in the vitamin D receptor (VDR) gene, their clinical features and biochemical parameters.
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- Pyoderma gangrenosum (PG) is an inflammatory skin condition that leads to painful, quickly developing ulcers and is often misdiagnosed due to its resemblance to other health issues; this study focused on its clinicopathologic characteristics and underlying conditions among patients in the Indian subcontinent.
- Over a ten-year period, the study identified 17 patients diagnosed with PG, predominantly affecting individuals in their early 30s, with ulcerative variants being most common; nearly a third had systemic associations with autoinflammatory syndromes.
- Treatments typically included systemic steroids and alternative medications, with more than half of the patients achieving remission within 2 to 3 months; however, there were
Pustular psoriasis is a specialized variant of psoriasis which can be life threatening if not treated at the earliest. The pathogenesis has been recently linked to the role of interleukin 36. Apart from the corticosteroids, systemic antipsoriatics like acitretin, cyclosporine and methotrexate have been used with some success though unpredictable.
View Article and Find Full Text PDFPsoriasis is a common chronic, immune-mediated inflammatory skin disease associated with various comorbidities. Managing psoriasis is often challenging as the therapy is decided based on the area of the disease, associated comorbidities and impairment in quality of life, besides the patient's preference. Making progress in the development of new molecules that can be used topically or orally, effectively controlling the disease with minimal side effects and providing long-lasting remissions are the needs of the hour.
View Article and Find Full Text PDFPsoriasis is a chronic and complex immune-mediated papulosquamous disease affecting almost 2% of the world population. The interaction between a genetically predisposed individual and environmental triggers leads to a vicious cycle involving autoreactive T cells, dendritic cells, keratinocytes and dermal cells. Up to 40% of the psoriasis cases develop disabling psoriatic arthritis and an equal number of patients also tend to develop metabolic syndrome as well as cardiovascular comorbidities; hence, this is no more considered to be a disease limited to skin only.
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