Publications by authors named "D Sarrut"
radiopharmaceutical therapy is a standardized systemic treatment, with a typical dose of 7.4 GBq per injection, but its response varies from patient to patient. Dosimetry provides the opportunity to personalize treatment, but it requires multiple post-injection images to monitor the radiopharmaceutical's biodistribution over time.
View Article and Find Full Text PDF. We introduce a versatile methodology for the accurate modelling of PET imaging systems via Monte Carlo simulations, using the Geant4 application for tomographic emission (GATE) platform. Accurate Monte Carlo modelling involves the incorporation of a complete analytical signal processing chain, called the digitizer in GATE, to emulate the different count rates encountered in actual positron emission tomography (PET) systems.
View Article and Find Full Text PDFBackground: Locally advanced non-small cell lung cancer (LA-NSCLC) reported poor 5-year survival rates with frequent local or regional recurrences. Personalized RT may contribute to improve control and clinical outcome. We investigated efficacy and tolerance of "Mid-position" (Mid-P) strategy versus the conventional Internal Target Volume (ITV) strategy in LA-NSCLC patients treated by definitive conformal radiotherapy.
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- The study investigates the out-of-field dose delivered during external photon beam radiation therapy, as it may lead to a higher risk of second cancers and affect immune system efficiency in radio-immunotherapy treatments.
- Traditional methods for estimating out-of-field doses are complex and not suitable for clinical use, prompting the exploration of deep learning techniques for more effective dose map prediction.
- A 3D U-Net model, trained on data from 3,151 pediatric patients, demonstrated promising results in estimating out-of-field doses, achieving low error rates in both training and validation, indicating potential for clinical application.
A Monte Carlo virtual source model named PHID (photon from Ion decay) that generates photons emitted in the complex decay chain process of alpha-emitter radionuclides is proposed, typically for use during the simulation of SPECT image acquisition.Given an alpha-emitter radionuclide, the PHID model extracts from Geant4 databases the photon emission lines from all decaying daughters for both isometric transition and atomic relaxation processes. According to a given time range, abundances and activities in the decay chain are considered thanks to the Bateman equations, taking into account the decay rates and the initial abundances.
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