Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice.

Depression is associated with dysregulated circadian rhythms, but the role of intrinsic clocks in mood-controlling brain regions remains poorly understood. We found increased circadian negative loop and decreased positive clock regulators expression in the medial prefrontal cortex (mPFC) of a mouse model of depression, and a subsequent clock countermodulation by the rapid antidepressant ketamine. Selective Bmal1KO in CaMK2a excitatory neurons revealed that the functional mPFC clock is an essential factor for the development of a depression-like phenotype and ketamine effects.

The EcoChip: A Wireless Multi-Sensor Platform for Comprehensive Environmental Monitoring.

This paper presents the EcoChip, a new system based on the state-of-the-art electro-chemical impedance (EIS) technologies allowing the growth of single strain organisms isolated from northern habitats. This portable system is a complete and autonomous wireless platform designed to monitor and cultivate microorganisms directly sampled from their natural environment, particularly from harsh northern environments. Using 96-well plates, the EcoChip can be used in the field for real-time monitoring of bacterial growth.

Visual, Ultrasonographic, and Microscopic Study on Hyaluronic Acid-Based Gel.

Background: Hyaluronic acid (HA) fillers are commonly used for enhancement of lips, and for softening fine lines and correcting skin depressions.

Objective: This study sought to investigate whether the Vycross technology used for Volbella gel resulted in a cohesive gel, as documented in our previous studies with three other HA fillers (Restylane NASHA [Q-MED, Uppsala, Sweden], Esthélis Basic CPM™ [Anteis SA, Geneva, Switzerland], and Juvéderm Ultra 3 using Hylacross technology [Allergan, Irvine, CA, USA]).


Method: The "resistance traction test" and "cohesiveness test" were conducted according to standard methods.

Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982). IGR Breast Cancer Group.

Background: Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the breast (local relapse) or development of a contralateral tumor.