Timing of Therapeutic Extractions Can Affect En Masse Anterior Retraction: A Split Mouth Randomized Clinical Trial.

Objective: To investigate the effect of deferred timing of therapeutic extraction on the rate of space closure during en masse anterior retraction.

Methods: Twenty-six patients (aged 16-24 years) with bimaxillary protrusion, crowding <3 mm, requiring bilateral extraction of four first premolars were recruited. Permuted block randomization was done.

A pilot study on the efficacy of 10600 nm carbon dioxide laser ablation in treatment of eyelid margin lesions.

Objectives: Eyelid margin lesions cause discomfort by impeding both central and peripheral vision, depending on their position on the eyelids, thus hindering everyday routines. However, surgical excision, radiofrequency, electrocautery, and cryosurgery are employed for treatment, although they are complicated and have functional limitations. Carbon dioxide (CO) lasers were used to assess the efficacy, safety, and patient satisfaction with CO laser ablation in managing eyelid margin lesions.

Review of Pharmacological and Medicinal Uses of Punica granatum.

Pomegranates () are a fruit renowned for their rich history, diverse uses, and substantial health benefits. Current research on the botanical features, nutritional profile, and medicinal properties of pomegranates is summarized in this study. Botanically, the pomegranate is classified as a deciduous shrub with a unique fruit structure comprising numerous seeds, or arils, embedded in a leathery skin.

Multifaceted evaluation of pyrazole derivative (T4)-chitosan (CS) nanoparticles: Morphology, drug release, and anti-tumor efficacy in a rat model.

The development of targeted nanotherapeutics has emerged as a pivotal advancement in cancer treatment, aiming to enhance the efficacy and specificity of drug delivery while minimizing systemic toxicity. Due to their biocompatibility and modifiable surface properties, Chitosan-based nanoparticles have shown considerable promise in encapsulating and delivering therapeutic agents directly to tumor sites. This study investigates the potential of 1,5-diary pyrazole derivative (T4)-loaded chitosan (CS) nanoparticles as a novel anticancer agent, evaluating their physical characteristics, in vivo biodistribution, and therapeutic efficacy against cancerous cells.

1,5- diaryl pyrazole-loaded chitosan nanoparticles as COX-2 inhibitors, mitigate neoplastic growth by regulating NF-κB pathway in-vivo zebrafish model.

Non-steroidal anti-inflammatory drugs (NSAIDs) have been researched for their capacity to reduce cancer incidence, primarily due to their COX-2 inhibition properties. However, concerns have arisen regarding the precision of their targeting abilities. Nanoparticle approaches are revolutionizing cancer treatment by enabling targeted drug delivery, which enhances the efficacy and reduces the toxicity of chemotherapy.