Publications by authors named "D Sangthawan"
Purpose: A multimodality approach using concurrent chemoradiotherapy (CRT) followed by esophagectomy has been the standard treatment in patients with locally advanced esophageal squamous cell carcinoma (ESCC). Computed tomography (CT) is widely utilized to evaluate esophageal cancer before and after CRT. This study evaluated the utility of pretreatment maximal esophageal wall thickness on CT scans to predict treatment outcomes after CRT in patients with locally advanced ESCC.
View Article and Find Full Text PDFA randomized controlled trial comparing concurrent chemoradiation versus concurrent chemoradiation followed by adjuvant chemotherapy in locally advanced cervical cancer patients: ACTLACC trial.
J Gynecol Oncol
July 2019
Article Synopsis
- The study aimed to evaluate the effectiveness of adding adjuvant chemotherapy (ACT) after standard concurrent chemoradiation therapy (CCRT) in patients with locally advanced cervical cancer.
- No significant difference in response rates or survival outcomes was observed between patients who received only CCRT and those who also received ACT, although systemic recurrences were lower in the ACT group.
- The findings suggest that adding ACT does not enhance overall treatment effectiveness compared to CCRT alone, despite some benefits in reducing systemic recurrences.
Zinc deficiency is an important factor that impairs cellular immunity and contributes to low T lymphocyte counts in head and neck cancers. Persistent T lymphopenia is clinically relevant in terms of tumor persistence and/or recurrence. The primary objective was to evaluate the impact of zinc sulfate supplementation on the absolute numbers of circulating T lymphocytes and T lymphocyte subpopulations.
View Article and Find Full Text PDFRandomized study of antiinflammatory and immune-modulatory effects of enteral immunonutrition during concurrent chemoradiotherapy for esophageal cancer.
Nutr Cancer
September 2014
Concurrent chemoradiotherapy (CCRT) induces toxicities from inflammation and immunological suppression. Omega-3 fatty acids, glutamine, and arginine are therapeutic factors that can attenuate such inflammation and promote cellular immunity. The question is whether immunonutrition (IN) during CCRT reduces inflammation and improves the immune function in patients with esophageal squamous cell carcinoma (ESCC).
View Article and Find Full Text PDFObjective: To determine the efficacy of zinc sulfate supplementation in reducing ofradiation-induced oral mucositis and pharyngitis in head and neck cancer patients.
Material And Method: One hundred forty four head and neck patients were enrolled in a randomized, double-blind, placebo-controlled trial. Patients who received radiation therapy alone or postoperative radiation therapy were eligible.