Publications by authors named "D Sanchez-Ruiz"
The aim of this work was to evaluate two functional feeds for the gilthead seabream, Sparus aurata, containing low inclusion of two microalgae-based products (LB-GREENboost, LB; and LB-GUThealth, LB). Fish (12-13 g) were fed for 13 weeks a control diet or one of the four diets supplemented with both products at 0.5% or 1%.
View Article and Find Full Text PDFBackground: Long-term longitudinal studies with multimodal biomarkers are needed to delve into the knowledge of preclinical AD. Subjective cognitive decline has been proposed as a risk factor for the development of cognitive impairment. Thus, including individuals with SCD in observational studies may be a cost-effective strategy to increase the prevalence of preclinical AD in the sample.
View Article and Find Full Text PDFArticle Synopsis
- Subjective cognitive decline (SCD) might indicate early signs of Alzheimer's disease (AD), but the genetic and biomarker characteristics of SCD individuals are still not well understood.
- A study evaluated the influence of the APOE ε4 gene on SCD risk using data from the FACEHBI cohort and Spanish controls, revealing that SCD individuals had higher frequencies of the APOE ε4 allele than non-SCD individuals.
- Results showed that the amount of APOE ε4 was linked to higher cerebral amyloid levels, indicating that while APOE dosage accounts for part of the variability in amyloid levels, other genetic or epigenetic factors are likely also at play in SCD.
Objective: To investigate CSF markers involved in amyloid precursor protein processing, neuronal damage, and neuroinflammation in the preclinical stages of Alzheimer disease (AD) and participants with suspected non-Alzheimer pathology (SNAP).
Methods: We collected CSF from 266 cognitively normal volunteers participating in a cross-sectional multicenter study (the SIGNAL study) to investigate markers involved in amyloid precursor protein processing (Aβ42, sAPPβ, β-secretase activity), neuronal damage (total-tau [t-tau], phospho-tau [p-tau]), and neuroinflammation (YKL-40). We analyzed the relationship among biomarkers, clinical variables, and the APOE genotype, and compared biomarker levels across the preclinical stages of the National Institute on Aging-Alzheimer's Association classification: stage 0, 1, 2, 3, and SNAP.
Objective: The aim of this study is to value the hearing results obtained in our department following stapedectomy and the reasons of primary failures.
Material And Method: We present a retrospective study of 95 stapedectomies in 82 patients, performed from January 1997 to September 2002 at Hospital Xeral-Cies of Vigo (Pontevedra).
Results: Medium presurgical audiometric threshold was 65.