Publications by authors named "D Sanagustin"
Prevalence of clozapine-induced sialorrhea and its effect on quality of life.
Psychopharmacology (Berl)
January 2023
Rationale: Clozapine has proven to be superior to other antipsychotic drugs in the treatment of schizophrenia but is under-prescribed due to its potentially severe side effects. Clozapine-induced sialorrhea (CIS) is a frequent and extremely uncomfortable side effect, which remains understudied.
Objectives: To examine the prevalence of diurnal and nocturnal CIS in a sample of patients treated with clozapine, and to evaluate its impact on quality of life.
Background: Catatonia is an underdiagnosed and undertreated neuropsychiatric syndrome characterized by catalepsy, negativism, mutism, muscular rigidity, and mannerism, often accompanied by autonomic instability and fever. Although there is growing interest in studying cognitive impairments before and after catatonia, little is known about the cognitive features of the syndrome.
Methods: This systematic review was registered at PROSPERO (CRD42022299091).
Background: Immune mechanisms are part of the pathophysiology of mental disorders, although their role remains controversial. In depressive disorders a chronic low-grade inflammatory process is observed, with higher interleukin-6 (IL-6) values. Furthermore, in SARS-CoV2 infection, which is closely related to depressive disorders, there is a proinflammatory cascade of cytokines that causes systemic inflammation.
View Article and Find Full Text PDFCatatonia is an undertreated and underdiagnosed neuropsychiatric syndrome whose prognosis is benign if treated early, thus avoiding possible complications and compromising the health of patients. The latest epidemiological studies indicate a prevalence of catatonia of 9.2%, being frequent in medical pathologies (especially neurological ones), as well as in psychiatric pathologies.
View Article and Find Full Text PDFArticle Synopsis
- The study examined the relationship between mental disorders and psychopharmacological treatments during COVID-19 hospital admissions and their impact on patient mortality.
- A total of 2,150 patients were included, revealing that 45% had a history of mental disorders, and 12% received a new diagnosis during their stay; delirium was also noted in 10% of cases.
- The findings showed a 17% mortality rate, with a history of mood disorders and new delirium increasing mortality risk, while prior treatment with anxiolytics and antidepressants was linked to lower mortality risk.