Publications by authors named "D Sampelean"
Article Synopsis
- - The study investigates the link between specific genetic variations (SNPs) in interleukin genes (IL-23 and IL-27) and the susceptibility to multiple sclerosis (MS), finding that these variations can significantly influence disease risk.
- - A case-control study with 252 participants identified that certain IL-27 gene variants increase the odds of developing MS, while variations in the IL-23 gene appear to decrease the risk.
- - The findings suggest that individuals with specific haplotypes related to these interleukins have a higher risk of developing MS, highlighting the importance of genetic factors in autoimmune disease susceptibility.
Background: Non-alcoholic fatty liver disease (NAFLD) is an important cause of chronic liver diseases around the world. Paraoxonase-1 (PON1) is an enzyme produced by the liver with an important antioxidant role. The aim of this study was to evaluate PON1 serum concentration and gene polymorphisms in patients with NAFLD.
View Article and Find Full Text PDFDetermining Factors of Arterial Stiffness in Subjects with Metabolic Syndrome.
Metab Syndr Relat Disord
November 2018
Background: Metabolic syndrome (MS) is a clustering entity characterized by obesity, hypertension, hyperglycemia, dyslipidemia, and insulin resistance. Early detection of atherosclerosis is important in patients with MS because cardiovascular diseases are the main cause of mortality in these patients.
Methods: We aimed to investigate the factors influencing arterial stiffness, pulse wave velocity, and the augmentation index, respectively, in 150 subjects with MS (94 women and 56 men; mean age 60.
Introduction: Oxidative stress is one of the key mechanisms responsible for disease progression in non-alcoholic fatty liver disease. The aim of this study was to evaluate the serum levels of oxidative stress markers in patients with type 2 diabetes mellitus (DMT2) and non-alcoholic steatohepatitis (NASH) and test their relationships with clinical and biochemical patient characteristics, compared to patients with DMT2 without non-alcoholic fatty liver disease (NAFLD), and controls.
Materials And Methods: In all, 60 consecutive patients with DMT2 and NASH, 55 with DMT2 without NAFLD, and 50 age-and-gender-matched healthy subjects participated in the study.
Background: Hyaluronic acid (HA), ASAT to Platelet Ratio Index (APRI), ASAT/ALAT ratio, Fibrosis 4 score (FIB4) and FibroScan were studied as non-invasive markers of liver fibrosis (F) in chronic viral hepatitis B (CHB) and C (CHC), in an attempt to avoid the complications of liver puncture biopsy, considered the gold standard in the evaluation of F. The aim of our research was to study whether HA, APRI, ASAT/ALAT ratio, FIB4 and FibroScan are useful non-invasive markers in predicting severe F in Romanian patients.
Patients And Methods: This was a prospective multicenter transversal and observational study, which included 76 patients with CHB/CHC.