Publications by authors named "D Samocha-Bonet"

Diet has been linked to gut dysbiosis and the onset, course, and response to treatment of patients with IBD and metabolic disease. : This single-centre prospective case-control study investigated the relationship between dietary intake, metabolic profile, and stool microbial composition in 57 individuals with IBD in clinical remission and 24 healthy individuals (HC). Participants' baseline anthropometric measurements, serum metabolic parameters, lipid profiles, and oral and stool samples for microbiota testing were collected.

View Article and Find Full Text PDF

Background: Emulsifiers are implicated in the pathogenesis of inflammatory bowel disease (IBD). Few studies have examined emulsifier intake in people with existing IBD. We aimed to describe the frequency of exposure to 6 selected emulsifiers in a contemporary cohort of people with IBD and compare intake with healthy controls (HCs).

View Article and Find Full Text PDF

Liver disease is a major global health problem leading to approximately two million deaths a year. This is the consequence of a number of aetiologies, including alcohol-related, metabolic-related, viral infection, cholestatic and immune disease, leading to fibrosis and, eventually, cirrhosis. No specific registered antifibrotic therapies exist to reverse liver injury, so current treatment aims at managing the underlying factors to mitigate the development of liver disease.

View Article and Find Full Text PDF
Article Synopsis
  • The liver, skeletal muscle, and adipose tissue play crucial roles in insulin regulation and glucose balance, with varied insulin resistance (IR) phenotypes linked to diabetes risk in individuals.
  • This study examined metabolic profiles in a group of obese individuals without diabetes to find specific metabolites and lipids associated with different IR types in muscle, liver, and fat tissues.
  • Results showed unique plasma signatures for distinct IR phenotypes and differentiated between types of abdominal fat, offering potential for more personalized treatments for those with obesity.
View Article and Find Full Text PDF

Diabetes (type 2) and sensorineural hearing loss are common health problems manifested with ageing. While both type 1 and type 2 diabetes have been associated with hearing loss, a causal link has been difficult to establish. Individuals with diabetes have twice the incidence of hearing loss compared to those without diabetes and those with prediabetes have a 30% higher rate of hearing loss.

View Article and Find Full Text PDF