A comprehensive RCT in screening, surveillance, and diagnostic AI-assisted colonoscopies (ACCENDO-Colo study).

Background And Aims: Adenoma detection rate (ADR) serves as a primary quality metric in colonoscopy. Various computer-aided detection (CADe) tools have emerged, yielding diverse impacts on ADR across different demographic cohorts. This study aims to evaluate a new CADe system in patients undergoing colonoscopy.

How to navigate the many direct-to-consumer microbiota analyses and why to use them.

Gut microbiota analysis, until a few years ago an exclusive research tool, has recently begun to spread among doctors and nutritionists around the world as a means aimed at better understanding patient disorders. As often happens, the commercial push has literally exploded and today there are numerous companies that offer microbiota analysis of dubious quality and/or as a business appliance aimed at selling supplements and the like. For non-experts it can therefore be difficult to find one's way among the numerous proposals.

Enhanced Wear Resistance and Thermal Dissipation of Copper-Graphene Composite Coatings via Pulsed Electrodeposition for Circuit Breaker Applications.

Copper, though highly conductive, requires improved wear resistance and thermal dissipation in applications that involve continuous movement and current-induced vibrations, such as power breakers. Conventional solutions, such as copper-tungsten alloys or lubricant use, face limitations in durability, friction, or environmental impact. This study explores the development of copper-graphene (Cu-GNPs) composite coatings using pulsed electrodeposition to enhance the tribological, thermal, and mechanical properties of circuit breaker components by adopting an industrially scalable technique.

Apennine-Pyrenees disjunct distribution: an unusual biogeographic pattern revealed in flea beetles of the species-group (Coleoptera, Chrysomelidae).

European mountain systems have played a crucial role in shaping the distribution of species and of their genetic diversity during the Quaternary climatic changes, with the establishment of allopatric patterns across main mountain ranges. Here we investigated the evolutionary history of flea beetles of the species-group showing an uncommon disjunct biogeographic pattern across the Apennine and the Pyrenees. We applied a multilocus molecular approach and multispecies coalescent models to establish a phylogenetic and systematic framework for this morphologically homogeneous species-group and to estimate the time of main cladogenetic events underlying the origin of the Apennine-Pyrenees pattern.