Predictive factors for the diagnosis of coeliac disease in children and young people in primary care: A systematic review and meta-analysis.

Background: Coeliac Disease (CD) often has its onset in childhood and affects 1% of the population. This review aimed to identify important predictive factors for coeliac disease in children and young people which could help GPs decide when to offer testing.

Methods: We searched MEDLINE, Embase and Cochrane Library to April 2024.

Identifying early symptoms associated with a diagnosis of childhood, adolescent and young adult cancers: a population-based nested case-control study.

Background: Childhood, teenage and young adult (CTYA, 0-24 years) cancers are rare and diverse, making timely diagnosis challenging. We aim to explore symptoms and symptom combinations associated with a subsequent cancer diagnosis and to establish their timeframe.

Methods: Using the QResearch Database, we carried out a matched nested case-control study.

Presentation of B-cell lymphoma in childhood and adolescence: a systematic review and meta-analysis.

Background: The diagnosis of B-cell lymphoma, one of the commonest cancers seen in childhood and adolescence, is challenging. There is a crucial need to identify and delineate the prevalence of associated symptoms in order to improve early diagnosis.

Aims: To identify clinical presentations associated with childhood and adolescent B-cell lymphomas and estimate symptom prevalence.

Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England.

The risk-benefit profile of COVID-19 vaccination in children remains uncertain. A self-controlled case-series study was conducted using linked data of 5.1 million children in England to compare risks of hospitalisation from vaccine safety outcomes after COVID-19 vaccination and infection.