Publications by authors named "D S York"
The Rev Response Element (RRE) forms an oligomeric complex with the viral protein Rev to facilitate the nuclear export of intron-retaining viral RNAs during the late phase of HIV-1 infection. However, our structural understanding of this crucial virological process remains limited. In this study, we determined several crystal structures of an intact RRE stem-loop II in two distinct conformations, performed negative-staining electron microscopy and molecular dynamics simulations, and revealed that this three-way junction RNA exhibits remarkable structural plasticity.
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- A new species named D.A.York & M.G.Simpson has been identified in serpentine barrens within the Shasta-Trinity National Forest, California, with an additional population found in Lake County.
- The new species shares similarities with two others, characterized by large corolla widths and specific nutlet shapes, yet differs in stem height, cymule structure, and nutlet count per fruit.
- This species is rare, adding to the group of eight known serpentine-adapted species, with ongoing research indicating a trend of convergent evolution in these plants' adaptations to their unique habitat.
MTR1 is an in vitro-selected alkyl transferase ribozyme that transfers an alkyl group from -alkylguanine to N1 of the target adenine in the RNA substrate (A63). The structure of the ribozyme suggested a mechanism in which a cytosine (C10) acts as a general acid to protonate -alkylguanine N1. Here, we have analyzed the role of the C10 general acid and the A63 nucleophile by atomic mutagenesis and computation.
View Article and Find Full Text PDFObjective: There is significant variation in out-of-hospital cardiac arrest (OHCA) outcomes between different regions. We sought to evaluate outcomes of OHCA patients in the interfacility transfer (IFT) setting, between critical care transport (LifeFlight) and community Emergency Medical Services (EMS), in the state of Maine.
Methods: This was a retrospective analysis of our institution's electronic medical record and the Maine EMS database.