Impact of the Good Samaritan Law on bystander intervention willingness and perceived legal risks in India.

Background: Road traffic crashes (RTCs) are a global health burden, particularly in India, where response times for first responders can be prolonged. Prior to enactment of a Good Samaritan Law (GSL) in 2016, involved bystanders could face criminal and financial liability for assisting at an RTC site. This study evaluates the impact of GSL on bystander RTC attitudes, awareness, and experiences in India, comparing outcomes pre- and post-GSL implementation across metropolitan cities (MCs) and nonmetropolitan cities (NMCs).

Genomic analysis across 53 canine cancer types reveals novel mutations and high clinical actionability potential.

A genomic understanding of the oncogenic processes and individual variability of human cancer has steadily fueled improvement in patient outcomes over the past 20 years. Mutations within tumour tissues are routinely assessed through clinical genomic diagnostic assays by academic and commercial laboratories to facilitate diagnosis, prognosis and effective treatment stratification. The application of genomics has unveiled a wealth of mutation-based biomarkers in canine cancers, suggesting that the transformative principles that have revolutionized human cancer medicine can be brought to bear in veterinary oncology.

Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.

The accrual of cancer mutation data and related functional and clinical associations have revolutionised human oncology, enabling the advancement of precision medicine and biomarker-guided clinical management. The catalogue of cancer mutations is also growing in canine cancers. However, without direct high-powered functional data in dogs, it remains challenging to interpret and utilise them in research and clinical settings.

Genomic tumor analysis provides clinical guidance for the management of diagnostically challenging cancers in dogs.

Objective: To evaluate the diagnostic, prognostic, and therapeutic utility of a cancer genomic diagnostic assay (SearchLight DNA; Vidium Animal Health) for diagnostically ambiguous cancer cases.

Animals: 69 privately owned dogs with ambiguous cancer diagnoses and for which the genomic assay was performed.

Procedures: Genomic assay reports generated between September 28, 2020, and July 31, 2022, for dogs with malignancy or suspected malignancy were reviewed to determine the assay's clinical utility defined as providing diagnostic clarity, prognostic information, and/or therapeutic options.

Intrinsic Evolution of Analog Circuits Using Field Programmable Gate Arrays.

Evolvable hardware is a field of study exploring the application of evolutionary algorithms to hardware systems during design, operation, or both. The work presented here focuses on the use of field programmable gate arrays (FPGAs), a type of dynamically reconfigurable hardware device typically used for electronic prototyping in conjunction with a newly created open-source platform for performing intrinsic analog evolvable hardware experiments. This work targets the reproduction of seminal field experiments that generated complex analog dynamics of unclocked FPGAs evolved through genetic manipulation of their binary circuit representation: the bitstream.