Earliest evidence for heavy metal pollution on wildlife in Middle Age Europe.

Effects of past anthropogenic metal pollution on the wildlife are understudied. We investigate trace element incorporation in the dentition of a 1000 BP-year-old brown bear from the Romanian Carpathians, an area known historically for strong metallurgical activities. Background values as well as unnatural high lead (Pb), lithium (Li) and zinc (Zn) levels in a circa 5‒6-year-old brown bear male were detected using trace element maps across its functional dentition.

Cancer drug resistance as learning of signaling networks.

Drug resistance is a major cause of tumor mortality. Signaling networks became useful tools for driving pharmacological interventions against cancer drug resistance. Signaling datasets now cover the entire human cell.

Provenance of late Pleistocene loess in central and eastern Europe: isotopic evidence for dominant local sediment sources.

Loess profiles along the Danube River provide a record of long-term Quaternary dust (loess) deposition in central-eastern Europe. Here, Sr-Nd isotopic data from four loess-palaeosol profiles (47 samples) spanning the last two-glacial-interglacial cycles are presented. The isotopic compositions generated by this study are compared with bedrock and sedimentary samples from Europe and North Africa to decipher the sources of sediment.

Occurrence and Time of Onset of Intraventricular Hemorrhage in Preterm Neonates: A Systematic Review and Meta-Analysis of Individual Patient Data.

Importance: Intraventricular hemorrhage (IVH) has been described to typically occur during the early hours of life (HOL); however, the exact time of onset is still unknown.

Objective: To investigate the temporal distribution of IVH reported in very preterm neonates.

Data Sources: PubMed, Embase, Cochrane Library, and Web of Science were searched on May 9, 2024.