Intracellular tenofovir-diphosphate concentrations in HIV pre-exposure prophylaxis users who underwent bariatric surgery.

Objective: To measure concentrations of tenofovir diphosphate (TFV-DP) in dried blood spots (DBS) among individuals taking tenofovir disoproxil fumarate plus emtricitabine (TDF/FTC) or tenofovir alafenamide plus emtricitabine (TAF/FTC) who were scheduled to undergo or had already undergone bariatric surgery.

Methods: We enrolled pre-exposure prophylaxis (PrEP) users attending clinics in Toronto or Ottawa who were undergoing or had undergone bariatric surgery. After participants completed a minimum of 7 days of consecutive PrEP dosing, we collected DBS samples immediately before they administered their next daily dose of PrEP.

First Report of Anthracnoseon on L. Caused by in China.

L. is a tropical fruit, cultivated in various provinces of China, such as Guangxi, Taiwan, and Yunnan. This fruit has good edible and medicinal value.

Understanding phage BX-1 resistance in AP-1 and the role of quorum-sensing regulation.

The marine ecosystem is characterized by a rich diversity of bacterial hosts and their phages. The propagation of phages is primarily limited by their ability to adsorb to host cells and is further challenged by various bacterial defense mechanisms. To fully realize the potential of phage therapy in aquaculture, a comprehensive understanding of phage-host interactions and their regulation is essential.

Experimental Investigation of Cadmium Isotope Fractionation during Adsorption on Montmorillonite and Kaolinite.

Cadmium (Cd) isotopes have recently emerged as novel tracers of Cd sources and geochemical processes. Widespread clay minerals play a key role in Cd migration due to their strong adsorption capacity, but the mechanism of Cd isotope fractionation during adsorption onto clay minerals is poorly understood. Here, we experimentally investigated the adsorption mechanisms of Cd on montmorillonite (2:1) and kaolinite (1:1) by using extended X-ray absorption fine structure (EXAFS) spectroscopy.

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition.

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. Elucidating the intricate interactions between cancer cells and the TME is crucial in understanding cancer progression and therapeutic challenges.