Evaluation of NMP22 in the detection of transitional cell carcinoma of the bladder.

Purpose: Urinary nuclear matrix protein (NMP22) was evaluated for detection of new and recurrent bladder tumors in patients with a history of transitional cell carcinoma. Our objective was to determine sensitivity and specificity of this marker for tumors of various stages and grades, as well as its use as an adjunct to or substitute for urinary cytology.

Materials And Methods: A total of 231 patients with a history of transitional cell carcinoma provided 288 voided urine samples before cystoscopic examination at 1 of 3 institutions (53 patients were reevaluated at least once).

The use of in bowel urology. Metabolic and nutritional complications.

Metabolic and nutritional complications of urinary diversion through bowel or stomach segments are common, but fortunately, not often severe. When metabolic abnormalities are problematic, deterioration or baseline insufficiency in renal function is the most likely cause. Deterioration is most commonly associated with obstruction or infection.

C-reactive protein as a marker for tissue damage in patients undergoing ESWL with or without retrograde stone manipulation.

In this study we attempt to evaluate the advantages and disadvantages of extracorporeal shock wave lithotripsy (ESWL) in situ versus retrograde stone manipulation before ESWL (ESWL+push back) in patients with proximal ureteral stones with regard to tissue damage and inflammatory processes. Several studies have revealed that C-reactive protein (CRP) is a useful marker for tissue damage and inflammation. Thirty patients following primary ESWL in situ, with residual calculi, were randomized to retreatment with ESWL in situ or ESWL+push back.

Inhibition of the sodium/hydrogen antiport by ammonium ion.

Purpose: Previous work from our laboratory suggests that one mechanism of ammonium transport across the intestinal membrane may be substitution of ammonium for sodium in the sodium/hydrogen antiport. This study further supports this mechanism by demonstrating an inhibitory role for ammonium in the sodium/hydrogen exchange.

Materials And Methods: Whole brush border intestinal enterocytes were studied, incorporating a fluorescent marker for sodium transport.