Publications by authors named "D S Spoor"
Radia Tamarat and Susana Constantino Rosa Santos were not included as authors in the original publication [...
View Article and Find Full Text PDFPurpose: To provide more insight into late treatment-related toxicities among breast cancer (BC) survivors by comparing morbidities and risk factors between BC survivors and age-matched controls.
Materials And Methods: All female participants diagnosed with BC before inclusion in Lifelines, a population-based cohort in the Netherlands, were selected and matched 1:4 to female controls without any oncological history on birth year. Baseline was defined as the age at BC diagnosis.
Radiation-Induced CardioVascular Disease (RICVD) is an important concern in thoracic radiotherapy with complex underlying pathophysiology. Recently, we proposed DNA methylation as a possible mechanism contributing to RICVD. The current study investigates DNA methylation in heart-irradiated rats and radiotherapy-treated breast cancer (BC) patients.
View Article and Find Full Text PDFPurpose: To assess sinoatrial node (SAN) and atrioventricular node (AVN) doses for breast cancer (BC) patients treated with 3D-CRT and evaluate whether "large" cardiac structures (whole heart and four cardiac chambers) would be relevant surrogates.
Material And Methods: This single center study was based on 116 BCE patients (56 left-sided, 60 right-sided) treated with 3D-CRT without respiratory gating strategies and few IMN irradiations from 2009 to 2013. The heart, the left and right ventricles (LV, RV), the left and right atria (LA, RA) were contoured using multi-atlases for auto-segmentation.
Article Synopsis
- Some studies say that radiation therapy for breast cancer might cause heart problems, but the details about how much radiation affects different heart parts weren't deeply explored.
- Researchers looked at breast cancer patients in a study to see if radiation caused heart issues, comparing patients with and without heart problems.
- They found 116 patients, but the results didn't show a clear link between radiation dose and heart issues, though more right-sided breast cancer patients had heart problems compared to those without.