Modifying Membranotropic Action of Antimicrobial Peptide Gramicidin S by Star-like Polyacrylamide and Lipid Composition of Nanocontainers.

Gramicidin S (GS), one of the first discovered antimicrobial peptides, still shows strong antibiotic activity after decades of clinical use, with no evidence of resistance. The relatively high hemolytic activity and narrow therapeutic window of GS limit its use in topical applications. Encapsulation and targeted delivery may be the way to develop the internal administration of this drug.

Uptake of Radionuclides Co, Cs, and Sr with α-FeO and FeO Particles from Aqueous Environment.

In the paper, investigation results of the uptake efficiency of radionuclides Co, Sr, and Cs dissolved in water onto iron oxides α-FeO and FeO are presented. It was found that sorption efficiency increased for higher pH values. Independent of the oxide nature, the uptake characteristics are the best toward Co and the worst toward Cs, forming the row as follows: Co > Sr > Cs.

Effect of SiC Addition to AlO Ceramics Used in Cutting Tools.

In this study, the effect of the addition of silicon carbide to alumina ceramics commonly used in cutting tool applications is addressed. Performance of AlO-SiC composite cutting inserts during the machining of hardened steels and ductile iron was compared to the results obtained for a cutting tool made out of 99 wt.% AlO, AlO-TiC, AlO-TiC-ZrO, and AlO-TiN.

Investigation of thioctic acid, magnesium stearate and pyridoxine hydrochloride compatibility.

To identify possible interactions of components in dosage forms, studies are usually carried out at the stage of pharmaceutical development. Such studies can predict compatibility of active pharmaceutical ingredients and excipients in order to optimize drug formulation and certain parameters of technological process. Compatibility of some components of a newly developed neuroprotective medicinal product Neuronucleos, namely, thioctic acid, pyridoxine hydrochloride, magnesium stearate and magnesium lactate, was studied by means of differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR).