Publications by authors named "D S Singh"
Draft genome sequence of DS1, a strain for high-acidity vinegar fermentation.
Microbiol Resour Announc
January 2025
The draft genome sequence of DS1 was isolated for high-acidity vinegar fermentation. The DS1 draft genome has a length of 8,793,442 bp, with 44.27% GC content, 3,053 proteins, 3,169 genes, and 15 genes that play an important role in acetic acid production.
View Article and Find Full Text PDFBackground: On demand, topical PrEP is desired by those preferring episodic, nonsystemic PrEP. PC-1005 gel (MIV-150, zinc, and carrageenan) exhibits in vitro antiviral HIV-1, human papillomavirus (HPV), and herpes simplex virus type 2 (HSV-2) activity, attractive for a multipurpose prevention technology candidate. We evaluated the safety, pharmacokinetics, and antiviral effect of rectally applied PC-1005.
View Article and Find Full Text PDFPurpose Of Review: Prader-Willi (PWS) and Angelman (AS) syndromes arise from errors in 15q11-q13 imprinting. This review describes recent advances in genomics and how these expand our understanding of these rare disorders, guiding treatment strategies to improve patient outcomes.
Recent Findings: PWS features include severe infantile hypotonia, failure to thrive, hypogonadism, developmental delay, behavioral and psychiatric features, hyperphagia, and morbid obesity, if unmanaged.
Glucocorticoid-induced osteoporosis (GIOP) is the most common type of secondary osteoporosis, marked by reduced bone density and impaired osteoblast function. Current treatments have serious side effects, highlighting the need for new drug candidates. Pyrimidine derivatives have been noted for their potential in suppressing osteoclastogenesis, but their effects on osteogenesis and GIOP remain underexplored.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness and safety of dentifrices containing Nano silver fluoride (NSF) against the bacteria Streptococcus mutans, which causes tooth decay.
- Researchers synthesized NSF particles and created dentifrices with varying concentrations of NSF, assessing their antimicrobial properties using an agar diffusion method and cytotoxicity on mouse macrophage cells.
- Results showed that NSF dentifrices inhibited bacterial growth effectively while also evaluating their impact on cell viability to ensure safety for use in oral health products.