Publications by authors named "D S S L Lera-Nonose"
Leishmaniasis is a neglected disease that affects millions of people worldwide, and special attention should be given to treatment because the available drugs have limitations, which can lead to low therapeutic adherence and parasitic resistance. This study evaluated the activity of the bioactive naphthoquinones, lapachol and β-lapachone, against Leishmania amazonensis. The cell alterations were evaluated in vitro on promastigote and amastigote forms.
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- The Phytolaccaceae family, part of the Caryophyllales order, includes plants used in traditional medicine, prompting a study to explore their potential antimicrobial properties.
- The research followed the PRISMA protocol and reviewed 95 publications, narrowing down to 22 articles that reported on the antimicrobial activities of various extracts from Phytolaccaceae plants, including antibacterial, antifungal, and antiviral effects.
- The study highlights the need for higher-quality research to confirm the clinical effectiveness of these plants and their potential as sources for new herbal medicines, while also emphasizing the importance of preserving these species for biodiversity.
The anti-Leishmania potential of bioactive compounds derived from naphthoquinones and their possible applications. A systematic review of animal studies.
Parasitol Res
May 2022
Leishmaniasis affects millions of people worldwide, and available treatments have severe limitations. Natural and derivative products are significant sources of innovative therapeutic agents. Naphthoquinones are natural or synthetic chemical compounds with broad biological activity.
View Article and Find Full Text PDFObjectives: The outcomes of tegumentary leishmaniasis (TL) rely on a complex interaction between the host immune system and the parasite. This study assessed the influence of polymorphisms in immune-related genes on TL.
Methods: Web of Science, Scopus, PubMed, and Embase databases were searched systemically.
Leishmaniasis is a neglected disease and drugs approved for its treatment often lead to abandonment, failure of therapy and even death. Photodynamic therapy (PDT) has been shown to be a promising, non-invasive and selective for a target region without requiring high-cost technology. Usually, it is employed a photosensitizing agent (PS) incorporated into nanoparticles (NP).
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