Publications by authors named "D S Peck"
Purpose: This prospective, longitudinal study was designed to determine the natural history of Fabry disease (FD) in early pediatric patients across the disease spectrum.
Methods: In this observational study of children under 5 years of age with variants in the gene, prospective phenotypic and urinary biomarker data were collected annually over 5 years.
Results: The study population included 40 participants (35 male, 5 female) with variants including 15 with classic pathogenic variants (CFD), 6 with nonclassic pathogenic variants (NFD), and 19 with a variant of uncertain significance.
Article Synopsis
- - The text discusses a rare complication called pseudoaneurysm that can occur in the right ventricular outflow tract (RVOT) after cardiac surgeries, particularly in a 3-month-old infant with tetralogy of Fallot and pulmonary atresia.
- - The patient was critically ill with septic shock and very high pressure in the right ventricle, requiring urgent treatment to avoid high-risk surgery.
- - The successful management involved using a Gore VBX balloon expandable covered stent to exclude the pseudoaneurysm and stenting the pulmonary arteries to relieve pressure, highlighting the importance of recognizing this condition and available treatment options.
Article Synopsis
- Endomyocardial biopsy is the standard method for monitoring heart transplant rejection, but this study explored a non-invasive index for assessing left ventricular relaxation in pediatric patients.
- The researchers analyzed data from 65 pediatric heart transplant patients who underwent 246 procedures to compare the new left ventricular relaxation index with traditional biopsy results for detecting cellular rejection.
- The findings showed that while the index had good sensitivity (100%) for identifying higher grades of rejection (2R and 3R), it lacked specificity (23%), indicating it may not be a reliable predictor of cardiac rejection in these patients.
Article Synopsis
- Blackwater rivers and streams have tea-colored water due to tannins from decaying plants, and these waters typically have lower pH and oxygen levels compared to non-blackwater systems.
- While blackwaters are most common in the eastern U.S., differences in water chemistry were found between blackwater and non-blackwater sites, but these differences varied by ecoregions, making it hard to generalize nationally.
- The study suggests the need for improved understanding and management of blackwaters through better definitions, identification of stressors, and consistent assessment methods to protect their unique ecological conditions.