Publications by authors named "D S PIERCE"
In this study we investigate the mechanics of type II collagen fibrils, an essential structural component in many load-bearing tissues including cartilage. Although type II collagen plays a crucial role in maintaining tissue integrity, the stress-stretch and failure response of type II collagen fibrils in tension is not established in the current mechanics literature. To address this knowledge gap, we conducted tensile tests on isolated collagen networks from articular cartilage and established a validated constitutive model for type II collagen fibril.
View Article and Find Full Text PDFWe report on the detection and quantification of aqueous DNA by a fluorophore-induced plasmonic current (FIPC) sensing method. FIPC is a mechanism described by our group in the literature where a fluorophore in close proximity to a plasmonically active metal nanoparticle film (MNF) is able to couple with it, when in an excited state. This coupling produces enhanced fluorescent intensity from the fluorophore-MNF complex, and if conditions are met, a current is generated in the film that is intrinsically linked to the properties of the fluorophore in the complex.
View Article and Find Full Text PDFAssociation between burnout and workplace climate in transplant clinical pharmacists.
Am J Health Syst Pharm
November 2024
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View Article and Find Full Text PDFArticle Synopsis
- Visceral pain in the large bowel, a key symptom of irritable bowel syndrome (IBS), is largely triggered by mechanical distension of the colon and rectum, prompting patients to seek gastroenterological care.
- This study aims to deepen understanding of how mechanical stimuli affect pain transmission in IBS through a detailed computational model that simulates the mechanical behavior of the mouse colorectum.
- The model explores various hypotheses on how mechanical stress influences nerve signaling, enabling insights into the neural and biomechanical factors of IBS pain and guiding future research in this area.
Background: Advance Care Planning (ACP) is critical to achieve goal-aligned care for patients. However, optimal implementation requires complex coordination and alignment across a healthcare system.
Measures: A survey of rapid response providers assessed usefulness of the ACP quality improvement bundle and perceptions of use and adherence.