Publications by authors named "D S Ornellas"
Background: In experimental sepsis, functional and morphological effects of bone marrow-derived mononuclear cell (BMDMC) administration in lung tissue have been evaluated 1 and 7 days after therapy. However, to date no study has evaluated the early effects of BMDMCs in both lung and kidney in experimental polymicrobial sepsis.
Material And Methods: Twenty-five female C57BL/6 mice were randomly divided into the following groups: 1) cecal ligation and puncture (CLP)-induced sepsis; and 2) Sham (surgical procedure without CLP).
Brilliant blue G, a P2X7 receptor antagonist, attenuates early phase of renal inflammation, interstitial fibrosis and is associated with renal cell proliferation in ureteral obstruction in rats.
BMC Nephrol
May 2020
Article Synopsis
- The study explores the role of purinergic P2X7 receptors (P2X7R) in kidney inflammation, apoptosis, and fibrosis following unilateral ureteral obstruction (UUO) in rats, specifically focusing on the effects at the three-day mark after UUO.
- Researchers administered a selective P2X7R inhibitor, brilliant blue G (BBG), to different groups of rats (UUO-BBG and UUO-V), analyzing kidney samples for various markers of inflammation and damage.
- Results indicated that BBG reduced the expression of inflammatory markers and renal cell apoptosis while promoting epithelial cell proliferation compared to the control group, suggesting its potential therapeutic role in managing kidney damage due to UUO.
Bone Marrow-Derived Mononuclear Cell Therapy Accelerates Renal Ischemia-Reperfusion Injury Recovery by Modulating Inflammatory, Antioxidant and Apoptotic Related Molecules.
Cell Physiol Biochem
June 2017
Background/aims: We investigated the regenerative capacity of intravenous administration of bone marrow-derived mononuclear cells (BMMCs) in a rat model of bilateral renal ischemia/reperfusion (IR) injury and the involvement of inflammatory anti-inflammatory and other biological markers in this process.
Methods: Rats were subjected to 1h bilateral renal pedicle clamping. BMMCs were injected i.
Objectives: The biologic effects of variable ventilation may depend on the etiology of acute respiratory distress syndrome. We compared variable and conventional ventilation in experimental pulmonary and extrapulmonary acute respiratory distress syndrome.
Design: Prospective, randomized, controlled experimental study.
We investigated the effects of acute hypercapnic acidosis and buffered hypercapnia on lung inflammation and apoptosis in experimental acute lung injury (ALI). Twenty-four hours after paraquat injection, 28 Wistar rats were randomized into four groups (n=7/group): (1) normocapnia (NC, PaCO2=35-45 mmHg), ventilated with 0.03%CO2+21%O2+balancedN2; (2) hypercapnic acidosis (HC, PaCO2=60-70 mmHg), ventilated with 5%CO2+21%O2+balancedN2; and (3) buffered hypercapnic acidosis (BHC), ventilated with 5%CO2+21%O2+balancedN2 and treated with sodium bicarbonate (8.
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