Publications by authors named "D S Melkonian"

Article Synopsis
  • Scientists studied how different types of epilepsy in rats show specific electrical patterns called spike-wave complexes (SWCs) during seizures.
  • They used special software to analyze the frequency of these SWCs in various models of epilepsy, including brain injuries and genetic conditions.
  • The research found that while the spike part of these complexes was similar across different models, the wave part varied a lot, which could help understand seizures better and develop treatments.
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This study examines how mental health and health behaviors evolved among college students nationwide before and during the onset of the COVID-19 pandemic. Data collected from college students across various campuses in Fall 2019 ( = 33,372) and Fall 2020 ( = 34,168) as part of the Healthy Minds Study. : The online survey was delivered Qualtrics.

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Objective: Prolonged electroencephalographic (EEG) monitoring in chronic epilepsy rodent models has become an important tool in preclinical drug development of new therapies, in particular those for antiepileptogenesis, disease modification, and treating drug-resistant epilepsy. We have developed an easy-to-use, reliable, computational tool for automated detection of electrographic seizures from prolonged EEG recordings in rodent models of epilepsy.

Methods: We applied a novel method based on advanced time-frequency analysis that detects EEG episodes with excessive activity in certain frequency bands.

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Probabilistic formalism of quantum mechanics is used to quantitatively link the global scale mass potential with the underlying electrical activity of excitable cells. Previous approaches implemented methods of classical physics to reconstruct the mass potential in terms of explicit physical models of participating cells and the volume conductor. However, the multiplicity of cellular processes with extremely intricate mixtures of deterministic and random factors prevents the creation of consistent biophysical parameter sets.

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Objective: Stress, pain, injury, and psychological trauma all induce arousal-mediated changes in brain network organization. The associated, high level of arousal may disrupt motor-sensory processing and result in aberrant patterns of motor function, including functional neurological symptoms. We used the auditory oddball paradigm to assess cortical arousal in children and adolescents with functional neurological symptom disorder.

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