Red blood cell alloantibodies after transfusion: factors influencing incidence and specificity.

Background: Alloimmunization after exposure to red cell (RBC) alloantigens depends on genetic and acquired patient-related factors, dose and route of administration, and the immunogenicity of the antigen, but exact kinetics are still unknown.

Study Design And Methods: A 5-year retrospective multicenter study analyzing factors influencing the rate and specificity of RBC alloimmunization was performed, with special emphasis on the time interval between transfusion event and antibody detection. Included were clinically significant alloantibodies against the Rhesus, Kell, Duffy, Kidd, and MSs blood group systems.

Inhibition of cell proliferation by lithium is associated with interference in cdc2 activation.

Lithium can interfere with embryonal development in a variety of organisms. We investigated the effect of lithium on the proliferation of early embryonal cells. [3H]Thymidine incorporation of non-committed mouse P19 embryonal carcinoma cells was inhibited by lithium treatment.

Statistical features in the lakes-straits model and the influence of hernias.

We evaluate numerically the mobility of DNA chains under field-inversion gel electrophoresis (FIGE) conditions in the framework of the lakes-straits model introduced by Zimm (Phys. Rev. Lett.