Publications by authors named "D S Kohane"
Objective: The current treatment of venous malformations (VMs) consists of medications with systemic toxicity and procedural interventions with high technical difficulty and risk of hemorrhage. Using nanoparticles (NPs) to enhance drug delivery to VMs could enhance efficacy and decrease systemic toxicity. NPs can accumulate in tissues with abnormal vasculature, a concept known as the enhanced permeation and retention (EPR) effect.
View Article and Find Full Text PDFHydrogel-based depots typically tend to remain where injected and have excellent biocompatibility but are relatively poor at controlling drug release. Nanoparticles (NPs) typically have the opposite properties. The smaller the NPs are, the more likely they are to leave the site of injection.
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- - Liposomes are effective drug delivery systems for cancer treatment, but PEGylated liposomal doxorubicin (sLip/DOX) causes skin toxicities due to their accumulation in the dermis.
- - The interaction between liposomes and neutrophils is crucial for liposome movement into the skin, as neutrophils recognize and capture liposomes via specific receptors.
- - By inhibiting complement activation or altering liposome surface properties, researchers found ways to reduce neutrophil uptake of liposomes, which may help decrease skin toxicity associated with sLip/DOX use.
Polymeric Prodrugs using Dynamic Covalent Chemistry for Prolonged Local Anesthesia.
Angew Chem Int Ed Engl
July 2024
Article Synopsis
- Depot-type drug delivery systems aim to provide a consistent and safe release of drugs over an extended period, minimizing initial toxicity, especially for potent substances like tetrodotoxin (TTX).
- The study developed a prodrug strategy using dynamic covalent chemistry to enhance TTX encapsulation in polymer nanoparticles, achieving over 90% efficiency while controlling release rates.
- In vivo tests showed that these polymeric prodrugs significantly reduced TTX's systemic toxicity and extended nerve block duration compared to free TTX, demonstrating potential for effective drug delivery systems.
Controlled release of low molecular weight hydrophilic drugs, administered locally, allows maintenance of high concentrations at the target site, reduces systemic side effects, and improves patient compliance. Injectable hydrogels are commonly used as a vehicle. However, slow release of low molecular weight hydrophilic drugs is very difficult to achieve, mainly due to a rapid diffusion of the drug out of the drug delivery system.
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