Publications by authors named "D S Klobassa"
Background: Neisseria meningitidis (Nm) is a nasopharyngeal commensal carried by healthy individuals. However, invasive infections occurs in a minority of individuals, with devastating consequences. There is evidence that common polymorphisms are associated with invasive meningococcal disease (IMD), but the contributions of rare variants other than those in the complement system have not been determined.
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- The EUCLIDS study investigated the impact of severe bacterial infections, like sepsis, among children in six European countries, analyzing data from 2,844 patients aged 1 month to 18 years over a three-year period.
- Findings revealed that around 43% of these children had sepsis, with pneumonia and central nervous system infections being the most common syndromes, while various bacteria such as Neisseria meningitidis and Staphylococcus aureus were frequently identified.
- The research highlighted that 37.6% of patients required intensive care, and among those with available outcome data, 2.2% experienced mortality, indicating a significant health burden from these infections.
Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS).
Crit Care
May 2018
Background: Sepsis is one of the main reasons for non-elective admission to pediatric intensive care units (PICUs), but little is known about determinants influencing outcome. We characterized children admitted with community-acquired sepsis to European PICUs and studied risk factors for mortality and disability.
Methods: Data were collected within the collaborative Seventh Framework Programme (FP7)-funded EUCLIDS study, which is a prospective multicenter cohort study aiming to evaluate genetic determinants of susceptibility and/or severity in sepsis.
Background Although recent reports suggest that the use of probiotics may enhance intestinal functions in premature infants, the mechanisms are unclear, and open questions remain regarding the safety and its efficacy. Objective The objective of this study is to evaluate the efficacy of probiotics on prevention of necrotizing enterocolitis in preterm infants in Nepal. Method We conducted a randomized, double blind, placebo controlled study of 72 hospitalized preterm infants.
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