Publications by authors named "D S Kass"
Immunoprecipitation is among the most widely utilized methods in biomedical research, with applications that include the identification of antibody targets and associated proteins. The path to identifying these targets is not straightforward, however, and often requires the use of chemical cross-linking and/or gel electrophoresis to separate targets from an overabundance of immunoglobulin protein. Such experiments are labor intensive and often yield long lists of candidate antibody targets.
View Article and Find Full Text PDFWe report hitherto elusive side-on η-bonded palladium(0) carbonyl (anthraquinone, benzaldehyde) and arene (benzene, hexafluorobenzene) palladium(0) complexes and present the catalytic hydrodefluorination of hexafluorobenzene by cyclohexene. The comparison with respective cyclohexene, pyridine and tetrahydrofuran complexes reveals that the experimental ligand binding strengths follow the order THF
cGMP plays a central role in cardiovascular regulation in health and disease. It is synthesized by NO or natriuretic peptide activated cyclases and hydrolyzed to 5'GMP by select members of the PDEs (phosphodiesterase) superfamily. The primary downstream effector is cGMP-dependent protein kinase, primarily cGK-1a (cyclic GMP-dependent protein kinase 1 alpha) also known as protein kinase G 1a in the heart and vasculature.
View Article and Find Full Text PDFArticle Synopsis
- - Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with no cure besides lung transplantation, and its mechanisms are not fully understood.
- - Research indicates that a deficiency in the innate immune receptor TLR5 increases the risk of IPF in humans and raises vulnerability to lung damage and fibrosis in mice; activating TLR5 protects against these issues.
- - The protective effects of TLR5 are linked to its role in promoting healthy microbial balance in the lungs, with disrupted microbiomes seen in both IPF patients and TLR5-deficient mice.
Article Synopsis
- Ambulatory oxygen is vital for patients with idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) who have low oxygen levels during physical activity, especially if traditional testing may miss their true needs.
- A study reviewed treadmill exercise tests for 329 IPF patients and 2,343 COPD patients to measure their oxygen flow requirements, finding that IPF patients typically need more oxygen than COPD patients at peak exertion.
- Notably, while some patients didn't need oxygen during moderate exercise, a significant portion (49% of IPF and 24% of COPD patients) required it when pushed to their highest level of exertion, highlighting the limitations of standard testing.