Publications by authors named "D S Kalra"
Background: Data quality is fundamental to maintaining the trust and reliability of health data for both primary and secondary purposes. However, before the secondary use of health data, it is essential to assess the quality at the source and to develop systematic methods for the assessment of important data quality dimensions.
Objective: This case study aims to offer a dual aim-to assess the data quality of height and weight measurements across 7 Belgian hospitals, focusing on the dimensions of completeness and consistency, and to outline the obstacles these hospitals face in sharing and improving data quality standards.
Background: Multiplexed Assays of Variant Effects (MAVEs) can test all possible single variants in a gene of interest. The resulting saturation-style functional data may help resolve variant classification disparities between populations, especially for Variants of Uncertain Significance (VUS).
Methods: We analyzed clinical significance classifications in 213,663 individuals of European-like genetic ancestry versus 206,975 individuals of non-European-like genetic ancestry from All of Us and the Genome Aggregation Database.
Purpose Of Review: To summarize selected late-breaking science on cardiovascular disease (CVD) prevention presented at the 2024 European Society of Cardiology (ESC) Congress.
Recent Findings: Key studies from the 2024 ESC Congress highlight advances in (CVD) management. Apolipoprotein A-1 infusions reduced risk in acute myocardial infarction patients with high LDL cholesterol.
Article Synopsis
- A narrative review analyzed peer-reviewed studies to explore how sleep-disordered breathing (SDB) links to cardiac arrhythmias through factors like intermittent hypoxia and autonomic imbalance.
- Patients with SDB face significantly higher risks for various heart rhythm issues, with more than double the chance of overall arrhythmias and a quadrupled risk of atrial fibrillation (AF).
- CPAP therapy is shown to be an effective treatment, reducing AF recurrence and lowering the risk of ventricular arrhythmias, emphasizing the need for early diagnosis and management of SDB to improve heart health.
A 43-year-old male patient with no known past medical history presented to the emergency department with new-onset bitemporal headache, dizziness, and bilateral lower extremity weakness for 1 day. The patient denied chest pain, shortness of breath, cough, or recent exposure to sick individuals. He was not on any medications and denied alcohol or illicit drug use.
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