Estimating the Impact of Aging on Visual Function Using Useful Field of View (UFOV) with a Focus on the Population of Gangwon-do in Korea.

Background/objectives: There is a need in Korea for research estimating the impact of aging using the Useful Field Of View (UFOV) test, which can evaluate visual function for elderly drivers.

Methods: This observational study involved young people in their twenties and thirties, later-middle-aged people in their fifties or older, and elderly people 65 or older recruited from the Gangwon-do region. UFOV testing was conducted on the participants where the participants completed a questionnaire about general and driving-related characteristics.

Multi-omic insights into molecular mechanism and therapeutic targets in spinocerebellar ataxia type 7.

Recent advances in molecular science have significantly enlightened our mechanistic understanding of spinocerebellar ataxia type 7. To further close remaining gaps, we performed a multi-omics analysis using SCA7 mice. Entire brain tissue samples were collected from 12-week-old mice, and RNA sequencing, methylation analysis, and proteomic analysis were performed.

Usability, efficacy, and safety of candidate tocilizumab biosimilar CT-P47 self-administration via auto-injector and pre-filled syringe in patients with rheumatoid arthritis: a single-arm, open-label, phase 3 study.

Background: CT-P47 is a candidate tocilizumab biosimilar that is currently in clinical development. We assessed the usability of CT-P47 self-administration via auto-injector (AI) in patients with rheumatoid arthritis (RA).

Research Design And Methods: This was a 12-week, single-arm, open-label, multiple-dose, Phase 3 study.

Comparison of Patients Who Were Not Evaluated and Lost to Follow-Up with Multidrug/Rifampin-Resistant Tuberculosis in South Korea.

Purpose: This study aimed to evaluate the prognosis of the not evaluated (NE) group by comparing it with the lost to follow-up (LTFU) group among patients with multidrug/rifampin-resistant tuberculosis (MDR/RR-TB).

Materials And Methods: This was a retrospective longitudinal follow-up study using an integrated database constructed by data linkage of the three national databases. This database included 7226 cases of MDR/RR-TB notified between 2011 and 2017 in South Korea.

Spectroscopic Signatures of Ultra-Thin Amorphous Carbon with the Tuned Disorder Directly Grown on a Dielectric Substrate.

The reduced structural complexity of atomically thin amorphous carbons makes it suitable for semiconductor technology. Inherent challenges arise from transfer processes subsequent to growth on metallic substrates, posing significant challenges to the accurate characterization of amorphous materials, thereby compromising the reliability of spectroscopic analysis. Here this work presents a novel approach: direct growth of ultra-thin amorphous carbon with tuned disorder on a dielectric substrate (SiO/Si) using photochemical reaction and thermal annealing process with a solid precursor.