Publications by authors named "D S Hobbs"

Article Synopsis
  • LEGO® therapy is found to be beneficial for younger autistic children in developing communication and social skills, while LEGO® robotics therapy may help autistic adolescents reduce anxiety and enhance social skills.
  • A study with 24 autistic students aged 13-16 examined the effects of 8-week LEGO® robotics therapy on anxiety, social skills, and engagement, using a mix of quantitative and qualitative data collection methods.
  • While no significant statistical differences were observed in the quantitative measures, qualitative feedback highlighted positive experiences, like improved school attendance, increased confidence, and enhanced social skills, suggesting further exploration of the therapy's benefits is warranted.
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Article Synopsis
  • The study investigates the genetic factors contributing to Alzheimer's disease by analyzing tau deposition through a genome-wide association study involving 3,046 participants.
  • It identifies the CYP1B1-RMDN2 locus as significantly linked to tau levels, with the variant rs2113389 explaining 4.3% of tau variation, while also correlating with cognitive decline.
  • Findings suggest a connection between CYP1B1 expression and tau deposition, offering potential new avenues for Alzheimer's treatment and understanding its genetic basis.
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Children with developmental coordination disorder (DCD) have difficulty learning and performing movements, often requiring increased feedback. Technology may be useful for delivering augmented feedback. Co-design methodology for developing therapeutic interventions has become popular in healthcare, including for technology in rehabilitation.

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Article Synopsis
  • Children with developmental coordination disorder (DCD) struggle with physical tasks, but task-specific practice and feedback can improve their motor skills.
  • This study aimed to assess the impact of various feedback types on motor learning and performance in children with DCD through a systematic review of 14 articles.
  • The findings showed no significant differences in outcomes based on feedback type, but all participants improved, indicating that both technology-assisted and traditional feedback methods are effective in enhancing motor performance.
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Introduction: Previous approaches pursuing in vivo staging of tau pathology in Alzheimer's disease (AD) have typically relied on neuropathologically defined criteria. In using predefined systems, these studies may miss spatial deposition patterns which are informative of disease progression.

Methods: We selected discovery (n = 418) and replication (n = 132) cohorts with flortaucipir imaging.

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