Publications by authors named "D S Graves"
Article Synopsis
- Periodontitis results from an imbalance between host immune responses and microbial interactions, leading to inflammation and loss of bone structure.
- The transition from gingivitis to periodontitis may be influenced by inflammation's proximity to bone, affecting bone resorption and formation.
- Recent research using single-cell RNA sequencing has revealed the distinct roles of various cell types in inflammation and bone remodeling, highlighting the complex interactions in conditions like periodontitis and orthodontic movement.
Advances in imaging technologies combined with artificial intelligence (AI) are transforming dental, oral, and craniofacial research. This editorial highlights breakthroughs ranging from gene expression mapping to visualizing the availability of global AI data, providing new insights into biological complexity and clinical applications.
View Article and Find Full Text PDFBackground: Recent studies suggest that lipid-lowering agents (LLA) may reduce chronic periodontitis, but it is unknown whether this benefit extends to people with type 2 diabetes (T2D).
Objective: We assessed the association between LLA use and periodontitis in Hispanic adults with T2D.
Design: This was a cross-sectional observational study.
Human adenoviruses (HAdVs) are small DNA viruses that generally cause mild disease. Certain strains, particularly those belonging to species B HAdVs, can cause severe pneumonia and have a relatively high mortality rate. Little is known about the molecular aspects of how these highly pathogenic species affect the infected cell and how they suppress innate immunity.
View Article and Find Full Text PDFArticle Synopsis
- PD-1 blockade therapy is approved for head and neck squamous cell carcinoma (HNSCC), but many patients don’t respond due to factors in the tumor microenvironment that promote resistance.
- The study reveals that the tumor-conditioned media (TCM) from HNSCC cells induces expression of the inhibitory receptor NKG2A on activated CD8+ T cells, impairing T cell activity and decreasing their ability to kill cancer cells.
- Understanding the small molecules in TCM that trigger NKG2A expression could lead to new cancer therapies and biomarkers to identify patients who might benefit from therapies targeting NKG2A.